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Glycomimetics: Modern Synthetic Methodologies Rene Roy

Glycomimetics: Modern Synthetic Methodologies

Rene Roy

Published January 1st 2005
ISBN : 9780841238800
Hardcover
202 pages
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 About the Book 

Modern Synthetic Methodologies Toward Glycomimetics contains 10 chapters describing the syntheses of natural and non-natural glycomimetics using modern transition metal catalyzed reactions. This book also contains several experimental detailsMoreModern Synthetic Methodologies Toward Glycomimetics contains 10 chapters describing the syntheses of natural and non-natural glycomimetics using modern transition metal catalyzed reactions. This book also contains several experimental details allowing the readers to get familiar with such intricate reactions using complex alkylidene carbenoids, samarium diodide, dicobalt octacarbonyl alkyne cyclotrimerization, and the like. The descriptions of biologically active carbohydrates are elegantly detailed. A new solution-phase glycopeptide synthesis using unprotected glycosyl amino acids as phase-tags is also described. Important strategies into the design of complex sialic acid C-saccharides, aryl C-glycosides, and conformationally restricted analogs of the important sialyl Lewis X are discussed. Tethering of carbohydrate residues through ester bonds and applications of the Tebbes methylenation and either ring closing metathesis or intramolecular C-glycosidations are used to provide novel carbohydrate analogs.